DNA Fragmentation Induced by Microcystin-RR in Mice Liver
نویسندگان
چکیده
Microcystins are cyclic heptapeptides synthesized by various genera of cyanobacteria where Microcystis is major toxin producing genera. Several variants (>100) of microcystin have been reported. Microcystins are highly toxic and hepatotoxic in nature. Microcystin intoxication in vertebrates mainly affects the intestine and liver although liver is the maximum affected organ. Microcystin toxicity induces DNA fragmentation as well as apoptosis in mice liver. Few earlier reports evidenced about DNA fragmentation induced by microcystin-LR (a microcystin variant). While for other microcystin variants including microcystin-RR, fewer studies have been done. During present study we have tried to find out the effect of microcystin-RR on DNA in mice liver. Results clearly indicate that microcystin-RR induces DNA fragmentation in mice liver.
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